This is a female patient, 36 years old, who was admitted to the Emergency Room in shock, with acute generalized abdominal pain.  The initial diagnosis was peritonitis and toxic megacolon.  She has clinical history of chronic diarrhea, lives in a rural zone and drinks non-treated water.

During surgery, the large bowel had multiple perforation, the mucosal surface was denuded and showed extensive hemorrhagic appearance.

3 H&E images from necrotic areas of the colon are submitted [See Histology]